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#neuroscience

32 posts31 participants2 posts today

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: sfari.org/2025/04/08/announcin
NLMFF: nlmfoundation.org/grant/epigen

SFARI · SFARI | Announcing the Recipients of the 2024 Pilot and Pilot Progression AwardsThe Simons Foundation Autism Research Initiative is pleased to announce funding for 23 projects as part of its 2024 Pilot and Pilot Progression awards.

Latest from Kathy Nagel's lab:

"Inhibitory control explains locomotor statistics in walking Drosophila", Gattuso et al. 2025
pnas.org/doi/abs/10.1073/pnas.

"we measure and analyze trajectories evoked by attractive odor in walking Drosophila and develop a biologically plausible computational model of trajectory generation and modulation by sensory input. Our model provides a link between neural architectures and locomotor behavior and highlights the potential role of inhibition in shaping the curvature and speed of trajectories. Inspired by this model, we experimentally identify single neurons and populations that modulate either curvature or speed in the manner predicted by our model."

#Consciousness #Neuroscience #thalamus
"A team of scientists has identified areas of the brain that are activated when a person becomes aware of themself and their thoughts."

Scientists Think They’ve Found the Region of the Brain That Regulates Conscious Perception

"A new experiment suggests that the thalamus plays a key role in humans becoming consciously aware of stimuli their brain receives."
wired.com/story/scientists-thi

WIRED · Scientists Think They’ve Found the Region of the Brain That Regulates Conscious PerceptionBy Jorge Garay

Imagine controlling machines with only your thoughts! Brain-Computer Interfaces (BCIs) are turning stuff of sci-fi into reality, and Mouser Electronics is leading the way.

Mouser has great content about this tech on their Empowering Innovation Together platform.
Check out mouser.com/empowering-innovation to see how their tech is shaping the future.

Thank you to Mouser Electronics for sponsoring Embedded.

👂 A team from the Laboratory for Soft Bioelectronic Interfaces has developed a flexible auditory brainstem implant (ABI) that closely conforms to the curved surface of the brainstem. The technology has successfully demonstrated high-resolution “prosthetic hearing” in macaques.

👉 go.epfl.ch/7df649

go.epfl.ch · Soft brainstem implant delivers high-resolution hearingEPFL researchers have developed a flexible auditory brainstem implant (ABI) that closely conforms to the curved surface of the brainstem. The technology has been successfully demonstrated high-resolution “prosthetic hearing” in macaques.

Scientists have just made a massive leap in neuroscience—creating an incredibly accurate digital twin of the human brain. This breakthrough could revolutionize how we treat neurological diseases, understand consciousness, and even explore the mind-machine interface. The future of brain science just got a lot more exciting!

@goodnews

#GoodNews #Neuroscience #BrainTech #DigitalTwin #FutureOfMedicine #AI #Innovation
thedebrief.org/the-holy-grail-

The Debrief · The "Holy Grail" of Neuroscience? Researchers Create Stunningly Accurate Digital Twin of the BrainScience, Tech and Defense for the Rebelliously Curious.

What did dopamine do to deserve this?

cognitivewonderland.substack.c

A guest post I did for tommy Blanchard's Cognitive Wonderland blog, about the surreal vilification of a vital neurotransmitter, and how this is having negative consequences for us all.

Cognitive Wonderland · What did dopamine do to deserve this?By Tommy Blanchard
Replied in thread

@pdbrooker I'm super interested to see where this takes you. How we construct meaning around multi-sensory experiences, and how our interaction with sound changes when we're experiencing ourselves making sounds, making sounds with others, etc. I think people in the #neuroscience field would have a research question ideas that could excite you for future interdisciplinary research projects on how your tools affect the way brains react to seeing + hearing + feeling + all at the same time. 🧠