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#ECM

1 post1 participant0 posts today
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Daniel Dvorkin

The F-35 is probably a better #fighter, on the whole, than the current version of the JAS 39. The F-47 will probably be better than the next version. But the best plane is the one you can get in the air.

Export restrictions, maintenance requirements, and the possibility of a "kill switch" make any US-built military aircraft a terrible bet for most customers. If Saab can find an alternate engine (the current powerplant is built by General Electric) then the #Gripen becomes a clearly better choice.

Saab claims its #ECM capabilities can be upgraded to make it the equal of any "stealth fighter." I don't know enough to evaluate this claim. I do know that if I were in charge of defense acquisitions for anywhere outside the US, I'd be willing to toss a coin to find out.

eurasiantimes.com/saab-offers-

EURASIAN TIMES · SAAB Offers 'Full-Capability' JAS-39 Gripens Amid "Pitch" Of Scaled-Down Version Of U.S. 6th-Gen F-47 FightersSaab offers all Gripen export customers the same high-end capabilities as enjoyed by Sweden, the primary operator of the combat aircraft. This challenges the norms of conditional defense exports and signals a shift toward greater operational sovereignty. In March 2025, U.S. President Donald Trump raised eyebrows by suggesting that the US allies would receive a “dumbed-down” […]
Public
Rxiv mechanobio

📰 "Rheological transition driven by matrix makes cancer spheroids resilient under confinement"
doi.org/doi:10.26508/lsa.20240
pubmed.ncbi.nlm.nih.gov/401479
#Mechanical #Matrix #Ecm

Life Science Alliance · Rheological transition driven by matrix makes cancer spheroids resilient under confinementCancer metastasis through confining peritoneal microenvironments is mediated by spheroids: clusters of disseminated cells. Ovarian cancer spheroids are frequently cavitated; such blastuloid morphologies possess an outer ECM coat. We investigated the effects of these spheroidal morphological traits on their mechanical integrity. Atomic force microscopy showed blastuloids were elastic compared with their prefiguring lumenless moruloid counterparts. Moruloids flowed through microfluidic setups mimicking peritoneal confinement, exhibited asymmetric cell flows during entry, were frequently disintegrated, and showed an incomplete and slow shape recovery upon exit. In contrast, blastuloids exhibited size-uncorrelated transit kinetics, rapid and efficient shape recovery upon exit, symmetric cell flows, and lesser disintegration. Blastuloid ECM debridement phenocopied moruloid traits including lumen loss and greater disintegration. Multiscale computer simulations predicted that higher intercellular adhesion and dynamical lumen make blastuloids resilient. Blastuloids showed higher E-cadherin expression, and their ECM removal decreased membrane E-cadherin localization. E-cadherin knockdown also decreased lumen formation and increased spheroid disintegration. Thus, the spheroidal ECM drives its transition from a labile viscoplastic to a resilient elastic phenotype, facilitating their survival within spatially constrained peritoneal flows. The raw data for all experiments and simulations will be made available upon reasonable request.
Public
Rxiv mechanobio

📰 "Empirical Hyper Element Integration Method (EHEIM) with Unified Integration Criteria for Efficient Hyper Reduced FE$^2$ Simulations"
arxiv.org/abs/2503.19483 #Physics.Comp-Ph #Mechanical #Math.Na #Cs.Na #Ecm

arXiv.orgEmpirical Hyper Element Integration Method (EHEIM) with Unified Integration Criteria for Efficient Hyper Reduced FE$^2$ SimulationsNumerical homogenization for mechanical multiscale modeling by means of the finite element method (FEM) is an elegant way of obtaining structure-property relations, if the behavior of the constituents of the lower scale is well understood. However, the computational costs of this so-called FE$^2$ method are so high that reduction methods are essential. While the construction of a reduced basis for the microscopic nodal displacements using proper orthogonal decomposition (POD) has become a standard technique, the reduction of the computational effort for the projected nodal forces, the so-called hyper reduction, is an additional challenge, for which different strategies have been proposed in the literature. The empirical cubature method (ECM), which has been proven to be very robust, implemented the conservation of the total volume is used as a constraint in the resulting optimization problem, while energy-based criteria have been proposed in other contributions. The present contribution presents a unified integration criteria concept, involving the aforementioned criteria, among others. These criteria are used both with a Gauss point-based as well as with an element-based hyper reduction scheme, the latter retaining full compatibility with the common modular finite element framework. The methods are combined with a previously proposed clustered training strategy and a monolithic solver. Numerical examples empirically demonstrate that the additional criteria improve the accuracy for a given number of modes. Vice verse, less modes and thus lower computational costs are required to reach a given level of accuracy.
Public *
Jonathan Townson

My next @preLights post is out. I saw this first preprint from the Storer lab a while back (thanks to a toot from @CellySally) and took some time over writing it but I think it was worth it!

I really enjoyed going back to some developmental biology with this study on how the ECM and mechanical environment influence limb regeneration. Also, nice that my PhD department, PDN, was heavily involved!

prelights.biologists.com/highl

preLightsHyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration - preLightsMui and team show hyaluronic acid deposition and a soft ECM promote digit regeneration in mice.
#preprint#regeneration#mechanosensing
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