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#neuropathy

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Malka Beth

@PostcardsFromParadise
@gardening Seed tape is meant as a convenience method, to evenly plant seeds without a machine.

It isn't really helpful to those like myself with #neuropathy, even as I'm sure if your #disability is that of limited energy & you can find what you want to grow in it's extremely limited plants/plant varieties, it would be useful. (This is why I don't use seed tape, as I'm the one doing the planting of our gardens & it's my spouse who's the person who can handle it decently & does have said limited energy. )

*Coated seeds which are at least a little more widespread in varieties with it than Seed tape, can help those with neuropathy especially in tiny items like most culinary herbs & lettuce, but wherever possible, I prefer to emphasize natural statuses as being helpful, as with these spinach seeds.

#Gardening#DisabilityAccessibility
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Malka Beth

@gardening #DisabilityAccessibility
For those with tactile problems &/or mild #neuropathy in your hands. I've a seed recommendation, namely Galilee #Spinach because said seeds beyond being about 1/8 the size of corn, also have spines extending beyond just the ball that's typical of spinach seeds.

Just putting them in to germinate today & I've never had an easier time of handling similarly sized seeds, even as my neuropathy is sizable today. #ChronicLife #Gardening

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OsteoarthriticAutistic

Both sensorimotor and autonomic neuropathy may be common in hypothyroidism, despite treatment
growkudos.com/publications/10.

#Hypothyroidism
#Neuropathy
#SyndromeT
#QuantativeSensoryTesting
#QST
#SensorimotorDysfunction
#HeartRateVariability
#HospitalAnxietyAndDepressionScale
#HADS
#StepUpDeiodinaseActivity

www.growkudos.comBoth sensorimotor and autonomic neuropathy may be common in hypothyroidism, despite treatmentA new study may provide a previously unknown reason for reduced quality of life in treated hypothyroidism (syndrome T). Systematic investigations of persons with treated hypothyroidism revealed unique signs of sensorimotor dysfunction in quantitative sensory testing (QST). Being marked by thermal and mechanical hypersensitivity, the pattern differs from the constellation seen in diabetes and other conditions leading to polyneuropathy. This may explain some of the sensory symptoms of syndrome T. Additionally, the study found reduced heart rate variability (HRV), depending on the titres of thyroid autoantibodies. This observation, indicating possible autonomic neuropathy, could explain the components of syndrome T that affect the circulatory system. Other results of the study included that both anxiety and depression were significantly more expressed in subjects with autoimmune thyroiditis and that they were also associated with antibody titres. The autonomic function significantly correlated with anxiety and depression, too. Additionally, the depression percentiles in the hospital anxiety and depression scale (HADS) were negatively associated with step-up deiodinase activity (SPINA-GD). In a control group with normal thyroid function, both autonomic and sensorimotor function correlated with the thyroid’s secretory capacity (SPINA-GT).
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DoomsdaysCW

A small town in rural Ohio is producing #EnrichedUranium again. Here's why that matters

The Ohio Newsroom | By Erin Gottsacker
Published April 18, 2024

"When Centrus Energy flipped three switches at its new plant last fall, it was a new beginning for an industry that had been dormant for more than a decade in #Ohio: #UraniumEnrichment.

"As the U.S. looks to meet its clean energy [sic] goals, there’s increasing demand for the resource, which is necessary for nuclear power generation.

"For years, the U.S. didn’t have a American-owned source of enriched uranium. (A subsidiary of #Urenco enriches #uranium in #NewMexico, but it's owned by a conglomeration of foreign governments and European-based businesses.) Now, #CentrusEnergy is attempting to fill in the gap. And it’s doing that at a plant in #PiketonOhio.

[...]

"Some locals aren’t thrilled. One group worries about the industry’s connection to #NuclearWeapons. Others fear the waste from the plant could #contaminate the surrounding #environment. The specter of the last time #uranium was being enriched in Piketon looms large: many former plant workers get federal compensation because of illnesses they sustained as a result of exposure to #toxic and #radioactive materials.

"'I feel violated,' said Vina Colley, a former worker at the #PortsmouthGaseousDiffusionPlant. 'They said I would get more radiation by getting on the plane than working out here.'

"In the time since she worked at the plant, she’s battled #beryllium disease, #ChronicBronchitis, #COPD, #neuropathy and #HeartFailure."

Read more:
wvxu.org/2024-04-18/a-small-to

WVXU · A small town in rural Ohio is producing enriched uranium again. Here's why that mattersBy Erin Gottsacker
#NoUraniumEnrichment#RadioactiveContamination#NewNuclear
Continued thread
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S t a c i e

UPDATE

I now have a mental health coach who suggested I get outside on my patio several times a week. Funny how it never occurred to me before.

💟🌟💟

I had friends stop by this week + it definitely helped.

💟🌟💟

It has been 3 weeks since I suspected I was gluten intolerant. So many symptoms have gone or significantly reduced so I don’t want to eat gluten again.

💟🌟💟

I’m still struggling with my mental health so I need to stay off social media for now.

💟🌟💟

#Today#MentalHealth#Neuropathy
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S t a c i e

My friend’s loss triggered my grief over my dad and grief brain took over for about a week.

😢🫠

I didn’t even know that was a thing.

My mental health is still on very shaky ground so I won’t be posting for now.

I discovered today while searching for something else that gluten intolerance could cause neuropathy, joint pain, as well as depression, anxiety, and brain fog. Going to see if being more restrictive with gluten will help.

#Grief#Today#FuckCancer
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Rhyothemis

from ⬆️ "These nettles are renowned for inflicting extremely painful stings that are characterized by acute electric shocklike, piercing, pricking and burning sensations lasting for many hours, followed by intermittent painful flares and allodynia that persists for days or even weeks."

Similarities to other types of neuropathic pain, including small fiber neuropathy and Long Covid associated neuropathy.

~

"These results provide important insights into the function of NaV channels in sensory neurons, identify TMEM233 as a previously unknown NaV1.7interacting protein, and describe the dispanins as bifunctional proteins that cause allosteric changes in channel gating upon binding of pain causing venom peptides."

~

Not finding much on TMEM233. Some dispanins are interferon activated.

review article from 2012:
- The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members
doi.org/10.1371%2Fjournal.pone

"The IFITM1–3 proteins were identified 25 years ago as being upregulated by interferons (IFN) [6]. Recently they received considerable attentions as IFITM1–3 were found to prevent infection of a growing list of viruses such as HIV-1, SARS influenza A H1N1, West Nile and Dengue fever viruses [7], [8], [9], [10]. Hence, proteins of the IFITM family mediate part of the antiviral response orchestrated by IFNs. However, the IFITM family is also involved in other processes such as oncogenesis, bone mineralization (IFITM5) and germ cell development (IFITM1 and 3) and IFITM5 has not been identified as interferon-inducible [11], [12], [13], [14]. Although the biological roles of the IFITM genes are emerging, no thorough evolutionary analysis has been performed on this group.

In this study, we sought to infer the evolutionary history of the human IFITM genes and identify potential homologues. We mined 36 eukaryotic species, covering all major eukaryotic groups, and found that the IFITMs form a subfamily in a larger novel family that has ten human members in addition to the four IFITM genes. We propose Dispanins as a novel name for this family, which refers to their common 2TM structure. "

journals.plos.orgThe Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human MembersThe Interferon induced transmembrane proteins (IFITM) are a family of transmembrane proteins that is known to inhibit cell invasion of viruses such as HIV-1 and influenza. We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which refers to a common 2TM structure. We mined the Dispanins in 36 eukaryotic species, covering all major eukaryotic groups, and investigated their evolutionary history using Bayesian and maximum likelihood approaches to infer a phylogenetic tree. We identified ten human genes that together with the known IFITM genes form the Dispanin family. We show that the Dispanins first emerged in eukaryotes in a common ancestor of choanoflagellates and metazoa, and that the family later expanded in vertebrates where it forms four subfamilies (A–D). Interestingly, we also find that the family is found in several different phyla of bacteria and propose that it was horizontally transferred to eukaryotes from bacteria in the common ancestor of choanoflagellates and metazoa. The bacterial and eukaryotic sequences have a considerably conserved protein structure. In conclusion, we introduce a novel family, the Dispanins, together with a nomenclature based on the evolutionary origin.
#TMEM233#dispanins#IFITM
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Emma Bee

@ddp for example Singh and colleagues explain "the impaired EO2 [peak O2 extraction] observed in the current study was attributed primarily to reduced oxygen diffusion in the peripheral microcirculation, resulting in increased peak exercise mixed venous oxygen saturation and peak venous O2 content" other parts of breathing seem unaffected and they conclude its not down to deconditioning. Plus they link to similar effects in #MECFS #neuropathy via the small fibre cholinergic response. #LongCovid

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Vayl Larkin (they/them)

14 years ago, I was diagnosed with #Sjögrens Syndrome. After about 4 years on methotrexate and Plaquenil, I had to go off the first due to protracted and severe side effects. 6 years later, I reached my lifetime toxicity limit and had to stop the Plaquenil forever. Today they diagnosed me with severe peripheral and CNS, motor and sensory #neuropathy. They're also saying there's nothing much they can do, as I am also allergic to gabapentin. Anyone have this? Any insights from those who do?

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Vayl Larkin (they/them)

Has anyone else experienced psychiatric side-effects with Methocarbamol as a muscle relaxant? I have spastic #neuropathy and was prescribed, but after a month of feeling increasingly anxious and angry, I spent four solid days awake. Did the math, called my doc, stopped the med, but boy heck was that horrid! I'm #Bipolar RC, and I take Abilify along with Strattera for my ADHD. I had a similar, but less severe reaction to Flexaril, but doctor assured me this was different. Any alternatives known?

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Jo-chin up, elbows up.

@Empathy1st #Kefir has been well studied as effective for Sars since the first Sars outbreak, & again for #COVID, proven to help t-cell regulation & a healthy gut biome, as well as brain function in #Alzheimers, etc.
KEFIR
nature.com/articles/s41598-021.
(Kefir & Alzheimers - #Neuropathy

ncbi.nlm.nih.gov/pmc/articles/ Kefir (probiotics) & COVID

ncbi.nlm.nih.gov/pmc/articles/ Kefir & COVID

pubmed.ncbi.nlm.nih.gov/331867
Kefir & COVID

thejournalofheadacheandpain.bi
Kefir & Neuropathy

#LongCovid#Healing#Health
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